“Sixth-generation (6G) wireless systems are envisioned to overcome 5G network limitations. In this paper, we explore recent advances made toward enabling 6G systems. We devise a taxonomy based on key enabling technologies, use cases, emerging machine learning schemes, communication technologies, networking technologies, and computing technologies. Furthermore, we identify and discuss open research challenges, such as artificial-intelligence-based adaptive transceivers, intelligent wireless energy harvesting, decentralized and secure business models, intelligent cell-less architecture, and distributed security models. We propose practical guidelines including deep Q-learning and federated learning-based transceivers, blockchain-based secure business models, homomorphic encryption, and distributed-ledger-based authentication schemes to cope with these challenges.”